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. 2021 Jan 11;11:430. doi: 10.1038/s41598-020-79948-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PAI-1 heterozygosity is associated with lower Pcsk9 and cholesterol profiles in HFHS fed mice. 20 week-old wild-type or Pai-1^+/− C57BL/6 J male mice fed HFHS diet. At the endpoint murine hepatic mRNA and plasma were analyzed. (A) Plasma PAI-1 levels. (B) Cholesterol content profile of the lipoprotein fractions resolved by FPLC from pooled samples (n = 6 for WT, n = 7 for Pai-1^+/−). (C) Plasma total cholesterol. (D) Hepatic PCSK9 mRNA expression normalized to GAPDH. Values are expressed as mean ± SEM (n = 6–7), * p < 0.05.