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. 2021 Jan 11;11:289. doi: 10.1038/s41598-020-79421-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bromelain reduced anxiety-like behaviour in sciatic nerve induced neuropathic pain in an elevated plus maze. Each values represent mean ± SEM of each group (n = 8). (A) Percentage of time spent at the open arm of the elevated maze (B) Number of entry into the open arm of the maze (C) Percentage of time spent at the close arm of the elevated maze (D) Number of entry into the close arm of the maze. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 compared with ligated control; *p < 0.05, **p < 0.01, ***p < 0.001 compared with normal control; ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001 compared with reference control. NC Unligated Normal Control, SC Sham Control, LC Ligated Control, GAB Gabapentin Reference Control (30 mg/kg gabapentin), LBr Low Dose Bromelain (30 mg/kg), HBr High Dose Bromelain (50 mg/kg), PLBr Pre-treated Low Dose Bromelain (30 mg/kg), PHBr Pretreated High Dose Bromelain (50 mg/kg).