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. 2021 Jan 11;11:289. doi: 10.1038/s41598-020-79421-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of bromelain on pro-inflammatory mediators in the sciatic nerve. Each values represent mean ± SEM of each group (n = 8). (A) IL-1β concentration (B) IL-6 concentration (C) TNF-α concentration (D) PGE₂ concentration. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 compared with ligated control; *p < 0.05, **p < 0.01, ***p < 0.001 compared with normal control; ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001 compared with reference control. NC: Unligated Normal Control; SC: Sham Control; LC: Ligated Control; GAB: Gabapentin Reference Control (30 mg/kg gabapentin); LBr: Low Dose Bromelain (30 mg/kg); HBr: High Dose Bromelain (50 mg/kg); PLBr: Pre-treated Low Dose Bromelain (30 mg/kg); PHBr: Pretreated High Dose Bromelain (50 mg/kg).