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. 2021 Jan 11;11:289. doi: 10.1038/s41598-020-79421-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bromelain improved neuronal myelination and down-regulated the expression of inducible nitric oxide synthase (iNOS) in the sciatic nerve. Bromelain attenuated the swelling and degeneration of myelinated neurons. It increased the myelination of neurons and mitigated the expression of iNOS. Red arrows indicate swelling of the myelinated neurons; black arrows indicate normal and non-swollen myelinated neurons, broken red arrows indicate expression of iNOS. (A) Unligated control (B) Sham control (C) Ligated control (D) Reference control (30 mg/kg gabapentin) (E) Low dose bromelain (30 mg/kg) (F) High dose bromelain (50 mg/kg) (G) Pre-treated low dose bromelain (30 mg/kg) (H) Pre-treated high dose bromelain.