Table 1.
ASD risk genes carrying germinal DNMs and PZMs in the Spanish cohort.
| Genes | q-value | p value | Mutations |
|---|---|---|---|
| SCN2A | 0.004 | 2.76 × 10–7 | Germinal |
| ARID1B | 0.050 | 2.76 × 10–6 | Germinal |
| CHD8 | 0.066 | 3.31 × 10–6 | Germinal |
| FIG4 | 0.103 | 9.39 × 10–5 | Germinal |
| RBM15 | 0.126 | 1.16 × 10–5 | Germinal |
| HUWE1 | 0.148 | 3.54 × 10–5 | Germinal |
| KIAA1107 | 0.188 | 5.08 × 10–5 | Germinal |
| VWAS5B1 | 0.218 | 5.08 × 10–5 | Germinal |
| EMCN | 0.242 | 6.13 × 10–5 | Germinal |
| SH2B2 | 0.262 | 7.90 × 10–5 | Germinal |
| ASMT | 0.277 | 9.34 × 10–5 | Germinal |
| MYLK4 | 0.291 | 9.67 × 10–5 | Germinal |
| KMT2C | 0.001 | 4.76 × 10–7 | PZM |
| FRG1 | 0.015 | 4.46 × 10–7 | PZM |
| GRIN2B | 0.040 | 4.76 × 10–7 | PZM |
| MAP2K3 | 0.08 | 6.67 × 10–6 | PZM |
| SRGAP2 | 0.106 | 7.62 × 10–6 | PZM |
| MBD6 | 0.124 | 7.62 × 10–6 | PZM |
| POTEB2 | 0.168 | 2.57 × 10–5 | PZM |
| CALML6 | 0.200 | 2.67 × 10–5 | PZM |
| PRDX6 | 0.226 | 3.05 × 10–5 | PZM |
| SSR2 | 0.245 | 3.14 × 10–5 | PZM |
| VEGFA | 0.264 | 4 × 10–5 | PZM |
| CANX | 0.278 | 0.0001 | PZM |
| ZNF276 | 0.290 | 0.00012 | PZM |
p values and q-values were obtained after running TADA-Denovo using germinal DNMs and PZMs from the Spanish ASD cohort (N = 360). Only genes with q-values < 0.3 are shown.