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. 2021 Jan 11;12:256. doi: 10.1038/s41467-020-20511-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Mll4 partners mainly with Nrf1 epigenetically activating the common target genes of Mll4 and Nrf1 by enhancing the levels of H3K4me1/2 and H3K27ac. These common targets also include the Nrf1 gene itself, resulting in indirect activation of Mll4-independent target genes of Nrf1 by Mll4 (i.e., indirect target genes of Mll4). Mll4 also partners with unknown transcription factors, for instance to activate Dlx1.