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. 2021 Jan 11;11:322. doi: 10.1038/s41598-020-79121-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Trend analysis of HLA-DR expression on monocyte (MON) subsets, CD4+ lymphocytes, CD8+ lymphocytes, and NK cells in PSN layout (presented in Fig. 3A). The y-coordinate of each dot in a scatterplot represents the expression value of studied markers in an individual patient. Values of all parameters were normalised to a maximum of 1 (the highest value in the data set). (B) Comprehensive visualisation of HLA-DR expression trends throughout the whole PSN. The unit on the x-axis is a pixel. The lines show the linear trend of the investigated parameter(s) obtained from scatterplots data.