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. 2021 Jan 11;11:374. doi: 10.1038/s41598-020-79624-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Spinal Cord Injury (SCI) induces an acute transcriptional response in the dorsal root ganglion (DRG) that differs from sciatic nerve injury (SNI). (A) Schematic of the experimental design for L4 DRG RNA sequencing after SNI and SCI. (B) Proportional Venn diagrams for differentially expressed (DE) genes upregulated (red) or downregulated (blue) after SNI (n = 3 mice) and SCI (n = 4 mice) (p-adj < 0.1). (C) Heatmap of known regeneration-associated transcription factors (RATFs) after SNI and SCI. (D) KEGG pathway analysis^17–19 of DE genes downregulated after SNI and upregulated after SCI. (E) Heatmap of genes associated with terpenoid backbone biosynthesis after SNI and SCI. (F) KEGG pathway analysis^17–19 of DE genes upregulated after SNI and downregulated after SCI. (G, H) Heatmap of genes associated with fatty acid biosynthesis and steroid biosynthesis after SNI and SCI.