Table 2.
Comparison of plasma GFAP between Aβ− and Aβ+ participants.
| Aβ− | (95% CI) | Aβ+ | (95% CI) | p | pa | |
|---|---|---|---|---|---|---|
| All participants | n = 63 | n = 33 | ||||
| 151.42 ± 58.49 | (129.66–173.18) | 240.12 ± 124.88 | (210.05–270.18) | 7E−6 | 5.76E−7 | |
| SMC | n = 49 | n = 25 | ||||
| 152.73 ± 58.18 | (126.35–179.11) | 252.22 ± 137.75 | (215.29–289.16) | b9E−6 | 4.8E−5 | |
| Non-SMC | n = 14 | n = 8 | ||||
| 146.83 ± 61.58 | (112.06–181.60) | 202.28 ± 63.81 | (156.28–248.27) | 0.059 | 0.020 |
Plasma glial fibrillary acidic protein (GFAP) levels were compared between cognitively normal older adults with low brain Aβ load (Aβ−) and high brain Aβ load (Aβ+) using linear models. All participants were further categorised into subjective memory complainers (SMC, n = 74) and non-complainers (non-SMC, n = 22). Data are presented in mean ± SD in pg/mL. p values in bold font were considered as significant (p < 0.05).
ap represents p values adjusted for age, sex, and APOE ε4 status.
bRepresents p values obtained from natural log transformed GFAP concentrations to better approximate normality when required.