Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 11;11:437. doi: 10.1038/s41598-020-80147-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

rTMS elevates concentration of dopamine and gene expression of DR4 in AD mouse model. The concentrations of neurotransmitters were measured after rTMS from tissue homogenates lysate of the hippocampus (a) Dopamine, (b) Acetylcholine, (c) Serotonin, and (d) Epinephrine. rTMS regulated dopaminergic signalling pathway through DR4. The expression of DR4 was measured by RT-PCR in (e) Hippocampus and (f) Cortex (g) Histograms show densitometry analysis of DR4 RT-PCR. Each group n = 3, mean ± SEM.*Ps < 0.05, ^# = 0.069. + Aβ42 oligomer injected via ICV, rTMS repetitive transcranial magnetic stimulation, DR4 Dopamine receptor 4, AD Alzheimer’s Disease, RT-PCR reverse transcription polymerase chain reaction, Aβ42 amyloid beta 42 oligomer, None none treatment, High high frequency rTMS treated, Low low frequency rTMS treated, N.S. not significant.