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. 2021 Jan 11;11:269. doi: 10.1038/s41598-020-79540-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mean geometric mean T₂ of intra- and extra-cellular water (IET2) values versus subject age (grouped by decade) within gray/white matter (GM/WM), external capsules (Ext Cap), cingulum, anterior/posterior/superior corona radiata (Ant/Post/Sup CR), anterior/posterior/retrolenticular internal capsule (Ant/Post/Retro IC), sagittal stratum (Sag Strat), all JHU labels (ALL), superior longitudinal fasciculus (SLF), posterior thalamic radiation (Post TR), fornix (Fornix), and genu/body/splenium of corpus callosum (G/B/S CC). Uncertainty bars were calculated as the standard deviation of values across subjects within each age group.