Table 4.

Multivariable MR model on skin-related cancers adjusting for episodes of childhood sunburn and pigmentation.

Risk factors in multivariate MR model	Outcome	Marginal BETA	SE	P-value	OR (95% CI) per unit change in risk factor
Episodes of childhood sunburn	Melanoma	0.33	0.26	0.21	1.39 (0.83–2.34)
Skin colour	Melanoma	0.06	0.25	0.81	1.06 (0.65–1.72)
25(OH)D concentration (SD unit)	Melanoma	0.15	0.11	0.18	1.16 (0.94–1.43)
Episodes of childhood sunburn	BCC	2.16	0.18	5.62E-34	8.63 (6.09–12.21)
Skin colour	BCC	−0.44	0.16	7.09E-03	0.65 (0.47–0.89)
25(OH)D concentration (SD unit)	BCC	0.14	0.07	0.07	1.15 (0.99–1.32)
Episodes of childhood sunburn	SCC	2.87	0.23	4.62E-35	17.68 (11.21–27.88)
Skin colour	SCC	−0.16	0.22	0.44	0.85 (0.56–1.29)
25(OH)D concentration (SD unit)	SCC	0.08	0.10	0.44	1.08 (0.89–1.31)

Marginal BETA reflects the marginal magnitude of association between the genetic effect of 25(OH)D SNPs exert on the risk factor of interest and skin cancer outcomes after conditioning on the genetic effect on remaining risk factors. All P-values are derived from z-scores of the MR association (two-sided) and unadjusted for multiple comparison unless otherwise stated.

BCC basal cell carcinoma, SCC squamous cell carcinoma.