Table 1.

Basic donor parameters.

	Control	Early-Onset AD	Late-Onset AD
Sex	12 M/14 F	7 M/9 F	8 M/10 F
Age (years)
M	70.7 ± 9.85	63.1 ± 5.61	82.9 ± 5.38*
F	70.8 ± 14.8	54.2 ± 7.16*	83.4 ± 6.35
PMI (hours)
M	16.7 ± 8.50	25.2 ± 10.6	22.7 ± 8.54
F	21.7 ± 12.7	18.5 ± 9.87	20.4 ± 7.98
Brain weight (grams)
M	1275 ± 155.1	1157 ± 139.2	1126 ± 98.9*
F	1191 ± 108.6	879.4 ± 143.4***	992.0 ± 94.9*

The brain samples analyzed for soluble Aβ peptides were obtained from neurologically normal cases (Control) and from histopathologically confirmed cases of Early-Onset or Late-Onset Alzheimer disease (AD). M, male; F, female; years (time-at-death; age at autopsy); PMI, post-mortem interval; *P < 0.05; ***P < 0.001; vs. control donors (mean ± sem).