Table 3.

Overview of the statistical significance of the predictive value of patients and graft characteristics for TAC concentration normalized by weight-adjusted dose (C/D/Kg). p values were calculated by multivariate linear regression analysis: only variables showing at least one significant p value by univariate analysis were included in the multivariate testing. NS = not significant and excluded from the model. CYP3A5 *1/*3 was coded as 1 while *3/*3 was coded as 2. GRWR was coded as percentage.

Days	TAC C/D/Kg (p values)
	1°	2°	3°	4°	5°	6°	7°	8°	9°	10°	11°	12°	13°	14°	15°
Regression R2	0.301	0.329	0.384	0.296	0.187	0.236	0.361	0.185	0.173	0.36	0.243	0.179	0.187	0.195	0.205
F statistic (d.f., res)	9.49	7.7	8.07	8.4	4.49	6.2	11.03	3.82	3.75	4.38	8.7	5.27	6.48	8.74	9.01
(d.f., res.) to put together with F statistic, as marked above	(2, 46)	(3, 45)	(3, 45)	(2,46)	(2, 46)	(2, 46)	(2, 46)	(2, 46)	(2, 46)	(2, 46)	(1, 47)	(1, 47)	(1, 47)	(1, 47)	(1, 47)
Donor CYP3A5 (Unstand. B coef.)	< 0.001	0.002	< 0.001	< 0.001	0.014	0.034	0.002	0.02	0.024	0.024	ns	ns	ns	ns	ns
(Unstand. B coef.) to put together with DONOR CYP3A5, as marked above	-9.2	− 75	− 107.4	− 87.3	− 40.6	− 60.1	− 43.4	− 35.2	− 45.4	− 12.7
GRWR (Unstand. B coef.)	0.558	0.326	0.01 (− 21.6)	0.039 (− 15.9)	0.022 (− 11.7)	0.004 (− 27.2)	0.001 (− 16.2)	0.027 (− 17.3)	0.045 (− 15.2)	ns	ns	ns	ns	ns	ns
Recipient age (Unstand. B coef.)	0.001 (4.1)	0.013 (2.8)	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
Recipient gender	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
Donor age	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
Donor gender (Unstand. B coef.)	0.008 (− 10.2)	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
INR day 1 (Unstand. B coef.)	ns	0.040 (− 35.5)	0.045 (5.1)	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns
INR day 5 (Unstand. B coef.)	ns	ns	ns	ns	ns	ns	ns	ns	Ns	0.042 (130.7)	0.001-(95.2)	0.012 (100.2)	0.005 (105.6)	0.001 (110.2)	< 0.001 (111.3)
Intercept	26.5	40	7.9	13.7	57.1	80.1	43.4	36.2	31.4	− 125	− 105	− 60.7	− 68.2	− 70.3	− 71.2