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. 2021 Jan 11;11:284. doi: 10.1038/s41598-020-78747-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ECV correlates with collagen fraction in skeletal muscles. Extracellular volume (ECV) was estimated from muscle T₁-maps acquired in vivo and plasma-T₁ measured in samples collected before and 1-h after Gd-CA injection. ECV was higher in fibrotic muscles after injury (a) and correlated with collagen fraction (b). Lines connect injured and control muscles for each animal in (a). (b) Scatter plot with fitted linear regression and 95% confidence interval in grey.