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. 2021 Jan 11;11:284. doi: 10.1038/s41598-020-78747-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased stiffness in fibrotic skeletal muscle. (a) Boxplots showing that ankle plantar flexion increases the shear-wave modulus in both injured and control muscles, from C57BL/6 and DBA/2J mice, but no difference between injured and control muscles could be detected (Supplementary Table S4). (b) The viscoelastic index was higher in injured muscles and (c) correlated with collagen fraction, indicating that muscle stiffness is increased in fibrotic muscles and that it can be detected non-invasively with SWE. Lines connect injured and control muscles for each mouse in (b). (c) Scatter plot with fitted linear regression and 95% confidence interval in grey.