Figure 7.
Combining non-invasive metrics to assess skeletal muscle fibrosis. Combining ECV and SMi (light orange line), ECV, SMi and T2 estimated from MSME data (red line) or ECV, SMi, T2 (MSME), short-T2* and Kurtosis (purple line) lead to AUCs always above 0.8. The combination of NMR and SWE metrics improved the ability to distinguish fibrotic (total collagen fraction from 15 to 25%) from non-fibrotic muscles (total collagen fraction up to 14%) non-invasively. Values are presented as AUC (95% confidence interval).