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. 2021 Jan 11;11:340. doi: 10.1038/s41598-020-79350-7

Figure 2.

Figure 2

KA dose selection for the induction of seizures in P21 mice. (a) Schematic of electrode placement in P21 mouse brain. (b) Representative EEG traces for mice injected with 5 or 7.5 mg/kg KA (KA—KA injection, LZ—lorazepam injection, X—mouse died). (c) Graph shows no difference in onset to first electrographic seizure after the IP injection of 5 (N = 4) or 7.5 (N = 3) mg/kg of KA. (d) Graph shows no difference in % of increase in EEG total power, relative to baseline, recorded over the 30 min after KA injection. (e) Representative images of FJB staining show neuronal death at 24 h post SE (5 mg/kg KA) in the right and left hippocampi of a P21 mouse.