Table 1.
Summary of demographic characteristics of enrolled participants.
| Total cohort | Individual PD participants accessed by TCR sequencing | Total cohort | Individual HC participants accessed by TCR sequencing | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | PD | 3450 | 3460 | 3486 | 3489 | 3529 | 3530 | HC | 3447 | 3452 | 3457 | 3459 | 3466 | 3487 | 3495 |
| Participants enrolled, n | 20 | 55 | |||||||||||||
| Age, median, range, years | 58.5 (51–73) | 58 | 51 | 73 | 62 | 55 | 57 | 66 (53–92) | 56 | 53 | 55 | 60 | 70 | 69 | 57 |
| Sex, male, % (n) | 60 (12) | M | F | F | M | M | F | 49 (27) | F | F | M | M | M | F | M |
| Caucasian, % (n) | 95 (19) | White | White | White | White | White | Asian | 93 (51) | White | White | White | White | White | White | White |
| Age at diagnosis of PD, median, range, yr | 55.5 (48–72) | 54 | 50 | 72 | 60 | 54 | 57 | N/A | – | – | – | – | – | – | – |
| Years since diagnosis, median, range, yr | 1 (0–4) | 4 | 1 | 1 | 2 | 1 | 0 | N/A | – | – | – | – | – | – | – |
| UPDRS, median, range | 24.5 (12–37) | 28 | 12 | 23 | 37 | 26 | 16 | N/A | – | – | – | – | – | – | – |
| MoCA, median, range | 25.5 (21–28) | 28 | 27 | 28 | 21 | 24 | 23 | N/A | – | – | – | – | – | – | – |
| LED, median, range | 250 (0–450) | 400 | 450 | 0 | 450 | 100 | 0 | N/A | – | – | – | – | – | – | – |
| Total SFC (α-syn, sum of IFNγ, IL-5 and IL-10) | – | 1057 | 2950 | 460 | 2097 | 2103 | 3200 | – | – | – | – | – | – | – | – |
| Total SFC (PT, sum of IFNγ, IL-5 and IL-10) | – | 100 | 3278 | 8947 | 14,620 | 7330 | 8087 | – | 1167 | 1367 | 2323 | 4350 | 14,900 | 1257 | 11,987 |