Table 2.
Neuron modules AD1/N1 are predicted to be targeted by differentially expressed TFs.
| Module name | Enriched TF | Differential expression in AD versus control | Number of predicted target genes in the module | Fisher’s exact test adjusted p value |
|---|---|---|---|---|
| AD1 | BCL6 | Up in 7/9 datasets | 119/1247 | 0.0095 |
| JUND | Up in 4/9 datasets | 116/1247 | 0.0148 | |
| ZBTB16 | Up in 5/9 datasets | 128/1247 | 0.0200 | |
| STAT3 | Up in 7/9 datasets | 204/1247 | 0.0449 | |
| MYB | Down in 4/9 datasets | 135/1247 | 8.87E-05 | |
| N1 | ZBTB16 | Up in 5/9 datasets | 112/1003 | 0.0058 |
| BCL6 | Up in 7/9 datasets | 97/1003 | 0.022 | |
| LEF1 | Up in 6/9 datasets | 273/1003 | 0.0337 | |
| STAT3 | Up in 7/9 datasets | 160/1003 | 0.0432 | |
| JUND | Up in 4/9 datasets | 94/1003 | 0.0359 | |
| MYB | Down in 4/9 datasets | 113/1003 | 6.271e-05 |