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. 2021 Jan 11;11:449. doi: 10.1038/s41598-020-80049-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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rDNA copy number estimates and correlations of 45S and 5S rDNA regions in the Simons Simplex Collection. (a) rDNA copy number distributions for probands (n = 1774) and unaffected siblings (n = 1774) in the Simons Simplex Collection. Paired t-test p-value: 0.937. (b) Comparison of 18S copy number in probands with low (I < = 50, n = 298) and high (I > = 100, n = 500) IQ scores. Welch Two Sample t-test p-value = 0.01533, average difference between groups is 9 copies. (c–e) Correlations of each the 18S, 5.8S, and 28S regions of the 45S rDNA array to the 5S rDNA array with Spearman’s rho indicated (n = 7210).