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. 2021 Jan 11;11:449. doi: 10.1038/s41598-020-80049-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Data quality metrics for rDNA copy number estimates. (a–d) Correlations between the 18S and 28S regions of the 45S rDNA repeat unit for the (a) high-coverage 1000 Genomes Project data (n = 2,419), (b) subset of high-coverage 1000 Genomes Project data also analyzed in the low-coverage dataset (n = 163), (c) low-coverage 1000 Genomes Project data (n = 163), and (d) Simons Simplex Collection data (n = 7,210). (e) Heritability of the 18S copy number in the Simons Simplex Collection (n = 3,548). (f) Heritability of the 5S rDNA copy number in the Simons Simplex Collection. (g,h) Comparison of 18S (g) and 5S (h) rDNA copy number estimates for either monozygotic twins (n = 4 pairs) or for individuals sequenced twice in the Simons Simplex Collection (n = 13). Spearman correlation indicated is for monozygotic twins and duplicates analyzed together.