Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 11;11:316. doi: 10.1038/s41598-020-79604-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Maternal hyperlipidemia is associated with sustained elevated blood pressures, enhanced contraction, and reduced relaxation functions of the mesenteric arteries. (A) Tail cuff systolic blood pressures (SBP) in male chow-exposed and high-fat-diet (HFD)-exposed offspring (n = 6 for each group). (B) Tail cuff SBP in female chow-exposed and HFD-exposed offspring (n = 6 for each group). (C) Intra-arterial cannulation SBP in 6-month-old chow-exposed and high-fat-diet (HFD)-exposed offspring (n = 5 for each group). (D) The contractile responses of the mesenteric arteries to phenylephrine in one-year-old HFD-exposed and control male rat offspring (Phe, n = 3). The concentration for 50% of the maximal effect (EC₅₀) in contraction is 3.973 × 10^–6 M (Chow-F1) and 2.063 × 10^–6 M (HFD-F1). (E) The endothelium-dependent vasorelaxation in the mesenteric arteries of one-year-old HFD-exposed and control male rat offspring (n = 3). The concentration for 50% of the maximal effect (EC₅₀) in relaxation is 3.794 × 10^–8 M (Chow-F1) and 1.705 × 10^–7 M (HFD-F1). Values in (A,B) are expressed as means ± SEs, ***p < 0.0001 **p < 0.01, *p < 0.05, compared to the corresponding control.