Figure 1.

The interaction of ZIKV E protein and human proteins. This diagram represents the set of potential ZIKV E protein domain III interacting proteins that were identified by a yeast two-hybrid experiment. The red circle indicates ZIKV E protein, grey circles indicate human proteins and light green circles indicate interacting proteins that have been previously implicated in replication of other viruses. For the interaction between each protein, light blue lines indicate interactions with evidence from curated databases, and purple lines indicate that the interaction was experimentally determined. The predicted interactions are indicated, green lines represent gene neighborhood, red lines represent gene fusion, and blue lines represent gene co-occurrence. Orange lines indicate co-expression and grey lines indicate protein homology.