Fig. 3.

(A) The inverse linear relationship between change in time in range (TIR) and change in glycosylated hemoglobin (HbA1c) differs by baseline HbA1c. A 10% increase in TIR only matches with a decrease of −0.4% of HbA1c in those with baseline HbA1c <7.0% but with a decrease of −1.0% in HbA1c in those with baseline HbA1c ≥8.0%. (B) The inverse linear relationship between TIR and mean glucose is preserved only in glucose values 120 to 200 mg/dL, and reversely falls when the glucose level decreases below 120 mg/dL. (C) The relationship between TIR and HbA1c differs by %CV. TIR was much lower in those with high %CV, even in those with the same HbA1c. Adapted from Beck et al. [22] and Rodbard [27], with permission from Mary Ann Liebert, Inc. CV, coefficient of variance.