Fig. 4. Time- and concentration-dependent metabolism of voglibose by intestinal microbiota in vitro. Various concentrations of voglibose was incubated with 0.5 g/mL intestinal contents prepared from both antibiotics- and vehicle-treated mice and incubated at 37℃ for various time points. The remained voglibose over time was measured by liquid chromatography-mass spectrometry (LC-MS/MS). Each bar represents the mean concentration of voglibose in the incubated sample+standard deviation of triplicate determinations. aThe value significantly different from corresponding vehicle-treated controls at P<0.05.
