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. 2021 Jan 12;6:15. doi: 10.1038/s41392-020-00376-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Regulation of DNA methylation by EBV (LMP1). The balance of DNA methylation- demethylation dynamics is maintained by DNMTs and TETs. DNMTs transfer methyl groups to cytosine and create 5mC. TETs iteratively oxidize 5mC to generate oxi-mCs (5hmC, 5fC, and 5caC). EBV (LMP1) enhances DNMT1 expression and activity, and also inhibit the enzymatic activity of TETs, which might tip the balance. FH fumarate hydratase, IDH2 isocitrate dehydrogenase 2