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. 2021 Jan 12;6:15. doi: 10.1038/s41392-020-00376-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — EBV-encoded proteins modulate host ubiquitin signaling pathways. EBV regulates degradation and non-degradation ubiquitination of key molecules in cell signaling pathways through hijacking host ubiquitinase and deubiquitinase, or directly encoding viral deubiquitinase. The ubiquitinases in orange cycle represents activated by EBV protein, and the gray represents for suppressed ubiquitinase