Table 1.
Hypermethylated genes in EBV-associated NPC
| Gene names | Full name | Gene function | Methylation status | Reference |
|---|---|---|---|---|
| APC | Regulator of WNT signaling pathway | WNT signaling | 34.0% (17/34) | 439 |
| CADM1 | Cell adhesion molecule 1 | Cell–cell adhesion | 69.8% (37/53) | 83 |
| 67.9% (19/28) | 440 | |||
| CDKN2A | Cyclin-dependent kinase inhibitor 2A, P16 | Cell cycle control | 66.0% (35/53) | 83 |
| CDH1 | E-cadherin | Cell–cell adhesion | 73.7% (18/28) | 441 |
| CDH13 | Cadherin 13 | Cell–cell adhesion | 77.4% (41/53) | 83 |
| CHFR | Checkpoint with forkhead and ring finger domains | Cell cycle control | 58.5% (31/53) | 83 |
| DAPK1 | Death-associated protein kinase 1 | Apoptosis | 27.3% (60/220) | 84 |
| DAB2 | DAB adaptor protein 2 | Proliferation | 65.2% (30/46) | 442 |
| DCC | DCC netrin 1 receptor | Signal transduction | 50.0% (23/46) | 439 |
| DLEC | DLEC1 cilia and flagella-associated protein | Proliferation | 60.4% (29/48) | 439 |
| DLC1 | DLC1 Rho GTPase activating protein | G-protein signaling | 76.9% (40/52) | 83 |
| 43.8% (21/48) | 439 | |||
| INPP4B | Inositol polyphosphate -4-phosphatase type II B | Phosphatidylinositol signaling | 60.0% (9/15) | 443 |
| ITGA9 | Integrin subunit alpha 9 | Cell–cell adhesion | 55.6% (20/36) | 444 |
| KIF1A | kinesin family member 1A | Membrane trafficking | 56.0% (28/50) | 439 |
| MAOA | Monoamine oxidase A | Amino acid metabolism | 40.7% (22/54) | 445 |
| miR-31 | microRNA 31 | Post-transcriptional regulation | 87.5% (14/16) | 446 |
| PRDM2 | PR/SET domain 2, RIZ1 | Histone methyltransferase | 56.6% (30/53) | 83 |
| PTEN | Phosphatase and tensin homolog | PI3K/AKT signaling | 80.0% (40/50) | 447 |
| RARB | Retinoic acid receptor beta | Nuclear receptor | 15.9% (35/220) | 84 |
| RASSF1A | Ras association domain family member 1 | Cell cycle control | 24.1% (53/220) | 84 |
| 75.5% (40/53) | 83 | |||
| 82.1% (23/28) | 440 | |||
| RASSF2A | Ras association domain family member 2 | Cell cycle control | 29.2% (14/48) | 83 |
| RRAD | Ras related glycolysis inhibitor and calcium channel regulator | Calcium channel | 74.3% (26/35) | 448 |
| UCHL1 | ubiquitin C-terminal hydrolase L1 | Protein ubiquitination | 64.0% (32/50) | 439 |
| WIF1 | WNT inhibitory factor 1 | WNT signaling | 51.8% (114/220) | 84 |
| 61.2% (30/49) | 83 | |||
| WNT7A | Wnt family member 7A | WNT signaling | 69.4% (25/36) | 444 |