Table 2.
Hypermethylated genes in EBV-associated GC
| Gene names | Full name | Gene function | Methylation status | Reference |
|---|---|---|---|---|
| AQP3 | Aquaporin 3 | Water channel | 95.8% (23/24) | 449 |
| B4GALNT2 | Beta-1,4-N-acetyl-galactosaminyltransferase 2 | Blood group systems biosynthesis | 50.8% (32/63) | 450 |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A, P16 | Cell cycle control | 86.7% (13/15) | 451 |
| 68.2% (15/22) | 452 | |||
| CDKN2B | Cyclin-dependent kinase inhibitor 2B, P15 | Cell cycle control | 86.7% (13/15) | 451 |
| CDH1 | E-cadherin | Cell–cell adhesion | 100% (15/15) | 451 |
| CYLD | CYLD lysine 63 deubiquitinase | Deubiquitination | 56.0% (14/25) | 453 |
| DAPK1 | Death-associated protein kinase 1 | Apoptosis | 73.3% (11/15) | 451 |
| IRF5 | Interferon regulatory factor 5 | Transcription factor | 76.5% (13/17) | 454 |
| MARK1 | Microtubule affinity regulating kinase 1 | Cell migration | 68.0% (17/25) | 455 |
| MINT2 | amyloid beta precursor protein binding family A member 2 | Signal transduction | 92.0% (23/25) | 452 |
| PTEN | Phosphatase and tensin homolog | PI3K/AKT signaling | 64.3% (18/28) | 456 |
| REC8 | REC8 meiotic recombination protein | Meiosis | 92.3% (12/13) | 457 |
| RUNX3 | RUNX family transcription factor 3 | Transcription factor | 96.0% (24/25) | 452 |
| S100A4 | S100 calcium binding protein A4 | Signal transduction | 50.0% (12/24) | 455 |
| SCRN1 | Secernin 1 | Exocytosis | 48% (12/25) | 455 |
| SOX9 | SRY-box transcription factor 9 | Transcription factor | 85.7% (6/7) | 458 |
| SSTR1 | Somatostatin receptor 1 | G-protein-coupled receptor signaling | 75% (9/12) | 459 |
| ST3GAL6 | ST3 beta-galactoside alpha- 2,3- sialyltransferase 6 | Glycosphingolipids biosynthesis | 44.4% (28/63) | 450 |
| TP73 | Tumor protein p73 | Stress response | 96.0% (24/25) | 455 |
| 100% (15/15) | 451 | |||
| 96.0% (24/25) | 452 | |||
| WNT5A | Wnt family member 5A | WNT signaling | 91.3% (21/23) | 460 |