Table 6.
EBV lytic proteins and tumorigenic functions
| Lytic protein | Lytic phase | Tumorigenic function |
|---|---|---|
| Zta | IE | Induction of IL-6, IL-8, IL-10, IL-13, and VEGF secretion |
| Rta | IE | Induction of genomic instability and progressive malignancy |
| BHRF1 | E | Anti-apoptosis |
| BARF1 | E | Anti-apoptosis |
| BCRF1 | E | Anti-apoptosis, homologous to IL-10 |
| BALF3 | E | Induction of genomic instability |
| BGLF4 | E | Induction of chromosomal abnormality and DNA damage |
| BGLF5 | E | Induction of genomic instability |
| DNase | E | Induction of genomic instability |
| BNLF2a | E | Immune evasion (inhibits the transporter of antigen processing) |
| BILF1 | E | Immune evasion (induces major histocompatibility complex (MHC) class I internalization and degradation) |
| BGLF5 | E | Immune evasion (mediates host shut‑off) |
| BNRF1 | L | Induction of centrosome amplification and chromosomal instability |