Table 2.
HHPred search with N-terminal part of four human TMTCs against Pfam-A_v33.1
| Pfam domain | TMTC1 (1–456) |
TMTC2 (1–475) |
TMTC3 (1–426) |
TMTC4 (1–462) |
|---|---|---|---|---|
| Glyco_transf_22 (PF03901, 388 AA) | 2.1E-20 | 1E-18 | 1.5E-20 | 6.4E-19 |
| Q: 29–456 | Q: 3–475 | Q: 9–426 | Q: 22–462 | |
| T: 1–352 | T: 1–351 | T: 2–350 | T: 1–350 | |
|
STT3 (PF02516, 458 AA) |
5.5E-19 | 2.1E-17 | 1.8E-19 | 9.5E-18 |
| Q: 26–456 | Q: 1–473 | Q: 5–423 | Q: 19–459 | |
| T: 3–406 | T: 4–400 | T: 3–401 | T: 3–401 | |
| PTPS_related (PF10131, 616 AA) | 1.4E-15 | 9.7E-14 | 2.5E-16 | 4.3E-15 |
| Q: 89–456 | Q: 62–475 | Q: 67–425 | Q: 81–462 | |
| T: 1–308 | T: 1–308 | T: 1–307 | T:1–308 | |
|
PMT (PF02366, 247 AA) |
2.3E-14 | 1.3E-13 | 1.5E-14 | 2.1E-13 |
| Q: 30–285 | Q: 3–248 | Q: 9–259 | Q: 23–293 | |
| T: 2–242 | T: 1–242 | T: 2–242 | T: 2–242 | |
| Mannosyl_trans2 (PIG-V) (PF04188, 432 AA) | 6E-14 | 1.9E-12 | 3.8E-14 | 1.4E-12 |
| Q: 51–451 | Q: 25–470 | Q: 30–426 | Q: 44–462 | |
| T: 60–425 | T: 60–425 | T: 60–429 | T: 60–427 | |
|
Dpy19 (PF10034, 651 AA) |
8.4E-13 | 1.8E-12 | 4.4.E-13 | 3E-12 |
| Q: 46–455 | 20–474 | 27–424 | 39–460 | |
| 30–502 | 30–503 (651) | 32–499 (651) | 30–499 (651) | |
|
AftA_N (PF12250, 432 AA) |
3.6E-12 | 3.7E-11 | 3.1E-13 | 1.6E-11 |
| T: 27–446 | T: 3–465 | T: 7–399 | T: 20–435 | |
| Q: 76–430 | Q: 78–431 | Q: 76–402 | Q: 75–402 | |
|
PMT_2 (PF13231, 159 AA) |
3.7E-13 | 1.1E-11 | 6.3E-13 | 1.6E-12 |
| Q: 91–276 | Q: 64–234 | Q: 69–250 | Q: 83–284 | |
| T: 1–156 | T: 1–156 | T: 1–156 | T: 1–159 | |
| Arabinose_trans (PF04602, 471 AA) | 6.3E-11 | 5.9E-09 | 1.1E-10 | 1.6E-10 |
| Q: 34–456 | Q: 8–468 | Q: 13–426 | Q: 27–462 | |
| T: 51–428 | T: 51–423 | T: 51–430 | T: 51–427 | |
|
PIG-U (PF06728, 363 AA) |
9.8E-11 | 7.8E-09 | 2.1E-10 | 5E-09 |
| Q: 47–456 | Q: 6–475 | Q: 14–423 | Q: 45–462 | |
| T: 30–349 | T: 1–350 | T: 1–345 | T: 35–349 | |
| Mannosyl_trans4 (PF15971, 163 AA) | 9.4E-11 | 1E-09 | 6.2E-11 | 3.9E-10 |
| Q: 81–276 | Q: 59–234 | Q: 59–250 | Q: 78–285 | |
| T: 1–162 | T: 6–161 | T: 1–162 | T: 6–162 | |
| Glucos_trans_II (PF14264, 312 AA) | 6.4E-07 | 2.8E-06 | 7.6E-08 | 5.6E-07 |
| Q: 45–413 | Q: 19–431 | Q: 24–385 | Q: 38–421 | |
| T: 5–310 | T: 5–310 | T: 5–310 | T: 5–310 | |
|
GT87 (PF09594, 251 AA) |
3.5E-07 | 6.4E-06 | 1.1E-06 | 1.5E-06 |
| Q: 91–389 | Q: 64–406 | Q: 68–360 | Q: 82–396 | |
| T: 2–251 | T: 2–249 | T: 1–248 | T: 1–248 |
The functionally annotated hits with best E-values are listed: PF03901, Alg9-like mannosyltransferase family; PF02516, Oligosaccharyl transferase STT3 subunit; PF10131, 6-pyruvoyl-tetrahydropterin synthase related domain, function unknown; PF02366, Dolichyl-phosphate-mannose-protein mannosyltransferase; PF04188, Mannosyltransferase (PIG-V); PF10034, Q-cell neuroblast polarisation, function unknown; PF12250, Arabinofuranosyltransferase N terminal domain; PF13231, Dolichyl-phosphate-mannose-protein mannosyltransferase; PF04602, Mycobacterial cell wall arabinan synthesis protein; PF06728, GPI transamidase subunit PIG-U; PF15971, Dolichyl-phosphate-mannose mannosyltransferase; PF14264, Glucosyl transferase Gtr II; PF09594, Glycosyltransferase family 87. For each query and each Pfam entry (listed as Pfam entry name and ID), we provide the E-value and the sequence ranges hit in the query (Q) and in the template (T; we also provide the length of the template in parentheses below the Pfam model name)