. 2021 Jan 5;12:683–693. doi: 10.2147/JEP.S289478

Table 4.

Packed Cell Volume, Rectal Temperature and Body Weight of Infected Mice Treated with Solvent Fractions of the Stem Bark of F. angolensis in the 4-Day Suppressive Test

Groups	Packed Cell Volume			Rectal Temperature			Body Weight
Groups	D₀	D₄	% Change	D₀	D₄	% Change	D₀	D₄	% Change
2% TW80	59.34±0.14	54.05±0.42	−9.79	36.52±0.14	34.62±0.33	−5.49	28.382±0.21	27.070±0.19	−4.85
CQ25 mg/kg	60.15±0.31	59.82±0.24	−0.55^a***	35.48±0.04	35.50±0.16	−0.06^a***	28.082±0.44	28.42±0.22	−1.19^a***
200 mg/kg CF	59.53±0.13	55.91±0.55	−6.47^a*b*	36.31±0.11	34.96±0.24	−3.86^ab**	28.142±0.09	26.96±0.35	−4.38^ab**
400 mg/kg CF	60.01±0.33	56.80±0.46	−5.65^a*b*	36.20±0.08	35.44±0.64	−2.14^ab*	27.972±0.55	26.98±0.42	−3.68^ab**
600 mg/kg CF	60.71±0.23	57.83±0.36	−4.798^a*b*	35.73±0.34	35.01±0.78	−2.06^ab*	28.162±0.33	27.21±0.42	−3.50^ab*
2% TW80	59.24±0.11	54.04±0.32	−9.62	36.53±0.14	34.59±0.71	−5.61	28.40±0.19	27.07±0.22	−4.91
CQ25 mg/kg	60.14±0.09	59.95±0.18	−0.32^a***	35.49±0.44	35.49±0.65	−0.00^a***	28.10±0.36	28.32±0.21	−0.78^a***
200 mg/kg BF	59.48±0.23	56.82±0.24	−4.68^{a*bde**}	36.37±0.34	35.07±0.09	−3.71^abe	28.01±0.39	26.95±0.19	−3.93^ab**
400 mg/kg BF	60.10±0.53	57.86±0.50	−3.87^a*b*	36.27±0.22	35.43±0.55	−2.37^a*b*	27.97±0.32	27.02±0.18	−3.52^ab**
600 mg/kg BF	60.75±0.33	59.20±0.26	−2.62^a*b*	35.79±0.32	35.13±0.39	−1.88^a*b*	27.66±0.52	26.88±0.23	−2.90^ab*
2% TW80	59.27±0.43	54.05±0.63	−8.70	36.5±0.24	34.59±0.44	−5.23	28.402±0.29	27.072±0.33	−4.68
CQ25 mg/kg	60.13±0.36	59.86±0.23	−0.45^a***	35.49±0.55	35.48±0.67	−0.03^a***	28.102±0.18	28.422±0.22	−1.14^a***
200 mg/kg AF	59.58±0.55	55.01±0.17	−7.67^a*b*	36.38±0.08	34.95±0.77	−3.93^ab**	28.172±0.35	26.972±0.29	−4.26^b***
400 mg/kg AF	60.05±0.73	55.7±0.39	−7.24^a*b*	36.24±0.55	35.04±0.23	−3.31^ab*	28.012±0.36	26.822±0.24	−4.25 ^b***
600 mg/kg AF	60.69±0.43	56.52±0.53	−6.87^a*b*	35.83±0.78	34.91±0.19	−2.57^ab*	28.232±0.56	27.122±0.22	−3.93 ^b***

Notes: Data are expressed as mean ± SEM; n = 6; ^aCompared with negative control; ^bTo CQ25 mg/kg; ^cTo 200 mg/kg; ^dTo 400 mg/kg; ^eTo 600 mg/kg; *p<0.05; **p<0.01; ***p<0.001

Abbreviations: CF, chloroform fraction; BF, butanol fraction; AF, aqueous fraction; 2% TW80, 2% Tween80; CQ, chloroquine; D₀, pre-treatment value on day 0; D₄, post- treatment value on day 4.