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. 2020 Dec 22;13(1):15. doi: 10.3390/cancers13010015

Figure 9.

Figure 9

Validation of array data in organotypic slice cultures (OSCs). (A) Heatmap of concordant genes (n = 200) sharing the same regulation after MALAT1 depletion in PCa cells (C27IM, DU145, and PC3) and OSC#28-12-11. Mean log2FC are represented with red stripes for upregulated genes and blue for downregulated genes. (B) Validation of MALAT1, ME3, PDK3, and PDK1 and CHKA as representative genes emerged from array analysis before (white bars) and after (green bars) MALAT1 depletion in different OSCs. Data are expressed as fold change vs. LacZgapmer (mean ± SEM). * p < 0.05 MALAT1gapmer vs. LacZgapmer.