Table 4.
Changes in the Prognostic, Nutritional and Laboratory Parameters in ACLD Patients After Discharge from the Hospital According to Adherence to ONS
| Baseline | Day 30 | Day 90 | Day 180 | Comparison vs Baseline | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D30 vs Baseline | D90 vs Baseline | D180 vs Baseline | |||||||||||
| n* | Median/% | Median/% | n* | Median/% | n* | Median/% | Median Difference | P | Median Difference | P | Median Difference | P | |
| Patients adherent to ONS | |||||||||||||
| MELD score | 173 | 15.00 | 14.00 | 97 | 13 | 59 | 12 | −1.00 | 0.0027 | −1 | <0.0001 | −2 | <0.0001 |
| Hand-grip strength (cm) | 168 | 24.85 | 26.00 | 86 | 29.1 | 58 | 26.1 | 0.90 | 0.0295 | 1.5 | 0.0023 | 2.2 | 0.0245 |
| Reractory ascites (%) | 123 | 16.30 | 21.20 | 74 | 14.9 | 48 | 16.6 | 4.88 | 0.1094 | 1.35 | 1 | 8.33 | 0.125 |
| Mid-arm ciscumference (cm) | 172 | 26.00 | 27.00 | 85 | 27 | 58 | 28 | 0.00 | 0.0787 | 1 | 0.0005 | 1 | 0.0021 |
| Tricipital skinfold (mm) | 171 | 11.80 | 13.50 | 85 | 14 | 58 | 13.8 | 0.00 | 0.4756 | 0.4 | 0.1401 | 0.8 | 0.157 |
| Mid-arm muscle area (cm2) | 170 | 39.80 | 40.40 | 85 | 42.7 | 58 | 42.6 | 0.40 | 0.4545 | 1.2 | 0.0668 | 2.9 | 0.0065 |
| Serum albumin (g/l) | 178 | 27.00 | 31.00 | 107 | 33 | 65 | 37 | 3.00 | <0.0001 | 4 | <0.0001 | 6 | <0.0001 |
| C-reactive protein (mg/l) | 177 | 10.10 | 8.30 | 105 | 6.1 | 66 | 4.7 | −0.40 | 0.0109 | −0.5 | 0.0082 | −1.3 | 0.0056 |
| Number connection test (s) | 172 | 96.50 | 81.00 | 87 | 76 | 59 | 79 | −6.00 | <0.0001 | −8 | 0.0005 | −11 | 0.0001 |
| Patients not adherent to ONS | |||||||||||||
| MELD score | 28 | 16.5 | 13.5 | 21 | 12 | 17 | 14 | −2 | 0.0056 | 0 | 0.1591 | 0 | 0.4143 |
| Hand-grip strength (cm) | 4 | 32 | 29.3 | 18 | 22.7 | 11 | 28 | 1.7 | 0.875 | 1.4 | 0.3465 | 3.2 | 0.4648 |
| Reractory ascites (%) | 22 | 27.3 | 22.7 | 17 | 35.3 | 16 | 6.3 | 4.55 | 1 | 5.88 | 1 | 25 | 0.125 |
| Mid-arm ciscumference (cm) | 4 | 24.5 | 25 | 18 | 28.5 | 11 | 29 | 0.5 | 0.1817 | −0.5 | 0.2676 | −2 | 0.375 |
| Tricipital skinfold (mm) | 4 | 8.2 | 8.3 | 18 | 15.2 | 11 | 18 | −1.6 | 0.875 | −2.2 | 0.4423 | −1.4 | 0.3203 |
| Mid-arm muscle area (cm2) | 4 | 38.6 | 40 | 18 | 42.5 | 11 | 39.3 | 1.8 | 0.125 | −0.83 | 0.766 | −4.8 | 0.5195 |
| Serum albumin (g/l) | 32 | 26 | 30 | 23 | 31 | 17 | 30 | 3 | 0.0013 | 3 | 0.0056 | 2 | 0.2435 |
| C-reactive protein (mg/l) | 31 | 10.7 | 7.4 | 25 | 5.8 | 17 | 9.8 | −1.5 | 0.1169 | −1.1 | 0.2879 | −1.1 | 0.7119 |
| Number connection test (s) | 4 | 103.5 | 93 | 18 | 99.5 | 11 | 99 | 7.5 | 0.875 | 6.5 | 0.9661 | 7 | 0.2061 |
Notes: *Available data for paired comparison (Wilcoxon test for numerilcal variables, McNemar test for proportions).
Abbreviation: ONS, oral nutritional supplements.