Figure 1 - . miR-149 directly binds the 3’-UTR of BACE1. A. The putative binding site of miR-149 at the 3’-UTR of BACE1. B. The luciferase activity results to confirm the interaction between miR-149 and BACE1. C. Serum expression of miR-149 detected by qRT-PCR. D. Serum mRNA expression of BACE1 measured by qRT-PCR. E. A negative correlation between serum miR-149 and BACE1 (r = -0.797, P < 0.001). F. A negative correlation between CF miR-149 and BACE1 (r = -0.780, P < 0.001). CF: cerebrospinal fluid; **P < 0.01; ***P < 0.001.