Figure 5 - . Expression of miR-149 in Aβ-treated SH-SY5Y cells and its negative regulatory effect on BACE1 expression. A. Aβ treatment in SH-SY5Y led to inhibited miR-149 expression, but cell transfection with miR-149 mimic significantly promoted the expression miR-149. B. The increased mRNA expression of BACE1 in Aβ-treated cells was inhibited by the overexpression of miR-149. C. The protein expression of BACE1 in Aβ-treated cells with miR-149 overexpression. **P < 0.01, ***P < 0.001 vs. Control; ^&& P < 0.01, ^&&& P < 0.001 vs. Aβ.