Table 3.

Clinical Bentley analysis of circPTPN22

Parameter	No. of patients	circPTPN22(high)	circPTPN22(low)	P-value
Sex
Male	72	34	38	0.456
Female	48	26	22
Age (years)
<60	43	18	25	0.183
≥60	77	42	35
Tumor size
<5	72	27	45	0.001***
≥5	48	33	15
Differentiation grade
Well-moderate	56	34	22	0.028*
Poor-undifferentiation	64	26	38
T stage
T1–T2	68	24	44	< 0.0001****
T3–T4	52	36	16
Lymph node status
Positive	75	24	51	< 0.0001****
Negative	45	36	9
TNM stage
I–II	52	15	37	< 0.0001****
III–IV	68	45	23
Nerve/vascular invasion
Positive	63	28	35	0.201
Negative	57	32	25

*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001