Table 1.

Normalized intensity comparison of differentially expressed microRNAs between SSc patients and HCs

MicroRNA	Log2 [fold change]	t test p value	Expression
hsa-miR-3682-3p	1.068379	0.013*	Upregulation
hsa-miR-4271	1.100022	0.096	Upregulation
hsa-miR-4481	1.381003	0.060	Upregulation
hsa-miR-4498	0.87481	0.004**	Upregulation
hsa-miR-4653-3p	1.788449	0.052	Upregulation
hsa-miR-4706	1.087915	0.046*	Upregulation
hsa-miR-4764-5p	0.776084	0.045*	Upregulation
hsa-miR-1207-5p	− 0.889822	0.460	Downregulation
hsa-miR-29b-2-5p	− 0.70392	0.008**	Downregulation
hsa-miR-320a	− 0.976112	0.033*	Downregulation
hsa-miR-320b	− 0.945275	0.002**	Downregulation
hsa-miR-320c	− 0.946686	0.034*	Downregulation
hsa-miR-320d	− 0.742298	0.035*	Downregulation
hsa-miR-320e	− 0.651448	0.020*	Downregulation
hsa-miR-324-5p	− 0.911236	0.060	Downregulation
hsa-miR-362-5p	− 0.601584	0.009**	Downregulation
hsa-miR-363-5p	− 0.924108	0.105	Downregulation
hsa-miR-3656	− 0.766701	0.058	Downregulation
hsa-miR-423-3p	− 0.792722	0.038*	Downregulation
hsa-miR-423-5p	− 1.155325	0.047*	Downregulation
hsa-miR-4284	− 0.69124	0.042*	Downregulation
hsa-miR-4508	− 0.653161	0.406	Downregulation
hsa-miR-4516	− 0.600174	0.300	Downregulation
hsa-miR-500a-3p	− 0.627692	0.003**	Downregulation
hsa-miR-652-3p	− 1.043636	0.061	Downregulation

Differentially expressed microRNAs were compared by both fold change test and t test

*p value < 0.05

**p value < 0.01