Fig. 5.

Fucoidan suppresses tumor growth in A549 cell xenograft mice in vivo. a. Representative images of subcutaneous A549 cell xenografts after surgical removal are shown. b. Tumor volumes and weights were measured. Tumor volume growth curves in mice from the fucoidan-treated and control groups.*p < 0.05. c. The tumor samples were homogenized, and immunohistochemical and western blot analyses of tumor samples were performed to detect the Ki-67 index. d. Immunofluorescence staining revealed the expression of VEGF-A and CD31 in tumor tissue. e. Immunofluorescence staining revealed the expression of N-cadherin and E-cadherin in tumor tissue