Table 2.
Potential clinical applications of circRNAs in OA
| CircRNA | Sample | Detection method | Expression | Parameter | Application | Ref |
|---|---|---|---|---|---|---|
| hsa_circ_0032131 | peripheral blood | qRT-PCR | ↑ | AUC (0.8455) | diagnostic biomarker | [108] |
| hsa_circ_0020014 | peripheral blood | qRT-PCR | ↓ | AUC (0.6415) | diagnostic biomarker | [109] |
| ciRS-7 | peripheral blood | qRT-PCR | ↓ | NA | diagnostic biomarker | [88] |
| hsa_circ_0104595 | synovial fluid | microarray analysis, qRT-PCR | ↑ | AUC (0.708) | diagnostic biomarker | [110] |
| hsa_circ_0104873 | synovial fluid | microarray analysis, qRT-PCR | ↑ | AUC (0.683) | diagnostic biomarker | [110] |
| hsa_circ_0101251 | synovial fluid | microarray analysis, qRT-PCR | ↑ | AUC (0.754) | diagnostic biomarker | [110] |
↑upregulation, ↓downregulation, AUC area under curve