Table 2.
Susceptibility loci associated with type 2 diabetes mellitus complications
| CHR | Closest gene | SNP | A1/A2 | OR (95% CI) | P-value | MAF cases/controls | MAF European |
|---|---|---|---|---|---|---|---|
| Diabetic neuropathy | |||||||
| 4:145030546 | GYPA | rs1132787 | T/C | 2.71 (2.02–3.64) | 3.23E−11 | 0.37/0.16 | 0.31 |
| 17:15733545 | LOC105371557 | rs522521 | A/C | 0.49 (0.38–0.64) | 5.07E−08 | 0.37/0.56 | 0.70 |
| Macrovascular complications | |||||||
| 1:144936353 | PDE4DIP | rs2477088 | T/C | 2.50 (1.87–3.34) | 6.11E−10 | 0.51/0.32 | 0.58 |
| 17:15733545 | LOC105371557 | rs522521 | A/C | 0.42 (17.32–0.56) | 6.95E−10 | 0.40/0.60 | 0.70 |
| 2:73870010 | NAT8 | rs4852954 | T/C | 2.27 (2.71–3.01) | 1.26E−08 | 0.50/0.31 | 0.61 |
| 1:169511555 | F5 | rs6032 | T/C | 2.12 (1.63–2.77) | 2.62E−08 | 0.56/0.37 | 0.73 |
| 6:167114208 | RPS6KA2 | rs6935464 | A/G | 2.25 (6.69–3.01) | 3.89E−08 | 0.44/0.26 | 0.57 |
| 18:14150724 | ZNF519 | rs7236163 | T/C | 2.14 (18.63–2.82) | 4.97E−08 | 0.46/0.27 | 0.58 |
| 7:76764970 | CCDC146 | rs3095447 | A/C | 2.16 (7.64–2.84) | 4.98E−08 | 0.55/0.37 | 0.79 |
| Ophthalmic complications | |||||||
| 7:76764970 | CCDC146 | rs3095447 | A/C | 2.18 (1.66–2.87) | 2.55E−08 | 0.61/0.40 | 0.79 |
CHR chromosome and base pair position in Human Genome build hg19, A1 minor allele, A2 major allele, OR odds ratio for the minor allele, CI confidence interval 95%, MAF minor allele frequency, MAF European minor allele frequency observed in the European population [31]