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. 2021 Jan 12;40:29. doi: 10.1186/s13046-021-01830-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Hsa_circ_0005273 upregulated YAP1 through targeting miR-200a-3p. A-C the expression of miR-200a-3p increased and the expression of YAP1 decreased after hsa_circ_0005273 was downregulated by RT-qPCR in BC cells. D The protein levels of YAP1/p-YAP1 to be decreased after transfection of si-circ_0005273 in BC cells by Western blotting. E-H MiR-200a-3p-inhibitor rescued the promotive effects of hsa_circ_0005273 in BC cells by MTT assay and transwell assays. I-K MiR-200a-3p-inhibitor reversed cell cycle arrest induced by si-hsa_circ_0005273. L-N Western blotting showed that miR-200a-3p-inhibitor can partly rescue the low expression of YAP1, p-YAP1 and PCNA caused by si-circ_0005273 in BC cells. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001