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. 2021 Jan 12;40:29. doi: 10.1186/s13046-021-01830-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Hsa_circ_0005273 inactivated Hippo signaling pathway. A-B LATS2/MST1 had low expression in BC tissues compared with adjacent normal tissues. C-D Negative correlations between the expression of hsa_circ_0005273 and LATS2/MST1 were found with Pearson’s correlation analysis in BC tissue samples (n = 45). E-G MRNA levels of MST1, LATS2 and YAP1 were tested in BC cells transfected with si-circ_0005273. H Protein levels of MST1, LATS1/2, YAP1 and their phosphorylation status were tested in BC cells transfected with si-circ_0005273. I Protein levels of YAP1 and p-YAP1 were tested in nucleus of si-circ_0005273 transfected BC cells. J, L, N and P Si-YAP1 rescued the promotive effects of hsa_circ_0005273 in BC cells by MTT assay and transwell assays. K, M and O Western blotting showed that si-YAP1 can partly rescue the high expression of YAP1 and p-YAP1 caused by LV-circ_0005273 in BC cells. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001