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. 2021 Jan 11;21:53. doi: 10.1186/s12885-020-07768-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Adhesion G protein-coupled receptors (adhesion-GPCR) gene microarray profiling in human retinoblastomas (Rb). a Expression data from the Childhood Solid Tumor Network at St Jude Children’s Research Hospital containing the RNA expression of 31 members of the adhesion-GPCR orphan receptors were analyzed in 11 fetal retinae compared to 64 Rb tumor samples. b Hierarchical cluster analysis show three clusters of adhesion-GPCRs in normal fetal retinae and Rb tissue samples. c, d Box and whiskers plots display significant upregulation of ELTD1 in Rb tumors compared to fetal retinae, (p < 0.0001) but no difference is detected in the RNA expression of GPR125 (p = 0.1731)