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. 2021 Jan 8;218(3):e20200839. doi: 10.1084/jem.20200839

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© 2021 Deuse et al.

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Figure S3. — Cytokine stimulation induces SIRPα expression on human NK cells. (A) Selected CD3⁻CD7⁺CD56⁺ primary NK cells showed a dose-dependent increase of SIRPα expression with IL-2 (representative histograms are shown of two independent experiments). (B) Unstimulated CD3⁻CD7⁺CD56⁺ primary NK cells did not express SIRPα but showed low-level expression of TIM-3 (representative histograms of two independent experiments are shown). (C and D) Five stimulatory cytokines for NK cells were assessed for their efficacy to induce SIRPα expression (C) and TIM-3 expression (B). While all five increased TIM-3, only IL-2, IL-15, and IFN-α increased NK cell SIRPα (representative histograms of two independent experiments are shown).