TABLE E1.

Posttransplantation complications in patients with GOF-STAT1 mutations

	Day after transplantation	Reversible	Fatal
Patient 1
Infection
EBV reactivation	+ 159	Yes	No
Recurrent pneumonia	+ 1464	Yes	No
Bleeding (coagulopathy associated with colitis)	+2765	Yes	No
CV
Catheter-associated thrombus	+ 159	Yes	No
SVT	+ 159	Yes	No
GI
Recurrence of colitis	+2756	Yes	No
Heme
Lymphopenia	+2249	No	No
Hypogammaglobulinemia	+ 1611	No	No
Secondary graft loss	+ 30	No	No
Patient 2 (first transplantation)
Infection
S parasanguis bacteremia	−2	Yes	No
CMV viremia	+ 19	Yes	No
Secondary graft loss	+ 33	No	No
Patient 2 (second transplantation)
Renal/GU
Drug-associated nephropathy	+ 28	Yes	No
GvHD	+ 30	Yes	No
Patient 3
GvHD	+ 16	Yes	No
Patient 4
Heme
Severe thrombocytopenia	+5	Yes (+490)	No
Lymphopenia	+ 30	No	no
Hypogammaglobulinemia	+ 304	No	No
Secondary graft loss	+ 120	No	No
Death (sepsis, pneumonia)	+779	No	Yes
Patient 5
Infection
CMV	Before transplantation	No	+7
GvHD	+ 10	Yes	No
Death	+ 12
Patient 6 (first transplantation)
Infection
Fungal pneumonia	+ 24	Yes	No
BK virus reactivation	+ 24	No	No
Patient 6 (second transplantation)
Infection
Adenovirus reactivation	+ 2	Yes	No
Cryptosporidium gut	+ 20	Yes	No
Fungal pneumonia	+ 74	No	Yes
GvHD	+ 17	Yes	No
Death	+4 mo	No	Yes
Patient 7: Turkey
Infection
Mycotic aneurysm	Before transplantation	No	Yes
Bleeding	+ 88	No	Yes
Death	+3 mo
Patient 8
CV
Cardiomyopathy	+ 1	No	Yes
Death	+3
Patient 9 (first transplantation)
Infection
S mitis sepsis	+ 22	Yes	No
Hemophagocytosis	+25 (first)	No	No
Secondary graft loss	+45	No	Yes
Patient 9 (second transplantation)
Infection	+ 14	No	Yes
Adenovirus viremia	+35
CV
Cardiac/pleural effusion	+ 21	No	Yes
GI
Ascites	+21	No	Yes
Renal/GU
Adenovirus cystitis	+29	No	No
Secondary graft loss	+32	No	Yes
Patient 9 (third transplantation)
Bleeding	+ 17	No	Yes
GI
Pancreatitis	+ 13	Yes	No
Death	+ 109	No	Yes
Patient 10: Japan
CV
TMA	+20	Yes	No
Lung
Acute pulmonary edema	+ 4	Yes	No
GI
Recurrent pancreatitis	−1, +32, +42, +53, +58, +63	Yes	No
Patient 11
Infection
Pulmonary aspergillosis	+ 150	Yes	No
GI
Hemorrhagic bleeding	+30	Yes	No
Renal/GU
Hemorrhagic cystitis	+ 18, +120	Yes	No
Heme
Lymphopenia	+50	Yes	No
Hypogammaglobulinemia	+50
GvHD
Skin	+ 7	Yes	No
GI	+ 17	Yes	No
Patient 12: Canada
Lung
Pulmonary hemorrhage	+20	No	Yes
GI
GI bleeding	+ 13	Yes	No
Renal/GU
Renal failure	+21	No	Yes
Other
TEN	+ 16	No	Yes
GvHD	+ 12	No	No
Death	+42	No	Yes
Patient 13: United Kingdom
GvHD	+50	Yes	No
Patient 14
Infection
CMV	+31	Yes	No
Candidiasis	+72	Yes	No
Sepsis	+214	Yes	No
Secondary graft loss	+ 28, +90	No	No
Death (sepsis)	+410	No	Yes
Patient 15
Infection
Pneumonia	+52, +300	Yes, no	No, yes
GI
Increased transaminase levels	+ 150	No	No
Heme
Severe thrombocytopenia	+ 150	No	No
Secondary graft loss	+ 130	No	No
Death	+10 mo	No	Yes

CV, Cardiovascular; CVM. cytomegalovirus; GI, gastrointestinal; GU, genitourinary; SVT, supraventricular tachycardia; TEN, toxic epidermal necrolysis; TMA, thrombotic microangiopathy.