Table 1.
Demographic characteristics and fasting glucose and hormone values of the study population
|
LRYGB |
LSG |
p values1 |
||||
| before surgery | 1 month after surgery | before surgery | 1 month after surgery | pre/post | OP type | |
| Weight, kg | 135.5±6.4 | 124.0±6.0; p < 0.0012 |
120.6±3.3 | 106.9±2.6; p < 0.0012 |
<0.001 | 0.034 |
| BMI | 44.7±1.4 | 40.9±1.3; p < 0.0012 |
42.4±0.8 | 37.6±1.0; p < 0.0012 |
<0.001 | 0.108 |
| BMI loss, % | 8.5±0.7 | 11.3±0.8 | 0.0203 | |||
| Glucose, mmol/L | 6.2±0.2 | 5.3±0.1; p = 0.0032 |
6.4±0.6 | 5.4±0.3; p = 0.0422 |
<0.001 | 0.838 |
| Insulin, µU/mL | 45.9±4.2 | 30.8±5.0; p = 0.0512 | 33.2±2.8 | 21.7±1.0; p = 0.0062 |
0.002 | 0.011 |
| HOMA-IR, µU/mL × mmol/L | 12.5±1.2 | 7.2±1.2; p = 0.0222 |
9.7±1.6 | 5.2±0.4; p = 0.0122 |
0.001 | 0.012 |
| C-peptide4, ng/mL | 3.1±0.5 | 3.4±0.4; p = 0.6732 | 3.2±0.4 | 3.2±0.5; p = 0.9412 | 0.751 | 0.948 |
| Amylin, pmol/L | 20.1±2.6 | 16.4±1.1; p = 0.1092 | 24.8±8.8 | 13.9±2.1; p = 0.1562 | 0.061 | 0.845 |
| Glucagon, pg/mL | 33.1±7.0 | 30.4±3.7; p = 0.6962 | 31.0±4.6 | 24.5±3.0; p = 0.0662 | 0.227 | 0.503 |
Data are given as means ± SEM. Statistically significant p values are italicized. LSG, laparoscopic sleeve gastrectomy; LRYGB, laparoscopic Roux-en-Y gastric bypass; BMI, body mass index; HOMA-IR, homoeostasis model assessment insulin resistance.
1
p values derived by general linear model analysis.
2
For each OP type, pre/post comparison was done by repeated measures analysis of variance (after surgery vs. before surgery).
3
Analysis of variance.
4
C-peptide values are available in 7 subjects per group.