. 2020 Nov 17;13(6):584–595. doi: 10.1159/000511928

Table 2.

Incremental area under the curve (AUC) after intravenous glucose and intravenous arginine stimulation

	LRYGB		LSG		p value¹
	before surgery	1 month after surgery	before surgery	1 month after surgery	pre/post	OP type	pre/post-surgery•OP-type interaction
Glucose, mmol/L
Glucose stim.
AUC_{0–60 min}	70±10	141+18, p = 0.016²	126±17	132±12, p = 0.752²	0.006	0.797	0.113
Arginine stim.
AUC_{0–60 min}	–50±12	21±11, p = 0.011²	–17±13	2±10, p = 0.185²	0.005	0.956	0.064

Insulin, µU/mL Glucose stim.
AUC_{0–60 min}	1,389±296	1,452±166, p = 0.852²	1,821±359	1,639±451, p = 0.778²	0.420	0.140	0.325
AUC_{0–10 min} (phase I)	446±134	547±89, p = 0.311²	468±126	495±91, p = 0.826²	0.841	0.209	0.314
AUC_10–60 _min (phase II]	943±183	905±125, p = 0.884²	1,353±254	1,144±389, p = 0.691²	0.345	0.327	0.338
Arginine stim.
AUC_{0–60 min}	250±248	628±272, p = 0.045²	428±225	641±261, p = 0.083²	0.440	0.441	0.056
AUC_{0–10 min} (phase I]	566±66	593±65, p = 0.768²	529±79	547±84, p = 0.869²	0.573	0.872	0.968
AUC_{10–60 min} (phase II]	–316±190	35±243, p = 0.291²	–133±265	94±202, p = 0.020²	0.218	0.271	0.841

Glucagon, pg/mL
Arginine stim.
AUC_{0–60 min}	–443±164	–222±262, p = 0.376²	–341±93	–172±122, p = 0.579²	0.876	0.551	0.538

C-peptide³, ng/mL
Glucose stim.
AUC_{0–45 min}	37±14	28±13, p = 0.691²	41±12	38±13, p = 0.733²	0.733	0.674	0.652

Amylin, pmol/L
Glucose stim.
AUC_{0–60 min}	58±85	32±46, p = 0.750²	115±151	61±60, p = 0.664²	0.680	0.096	0.580
AUC_{0–30 min}	46±49	51±33, p = 0.903²	80±94	54±36, p = 0.710²	0.526	0.046	0.332
AUC_{0–30 min}	44±19	49±28, p = 0.876²	122±44	61±26, p = 0.324²	0.990	0.152	0.970

Data are given as means ± SEM. Statistically significant p values are italicized. LSG, laparoscopic sleeve gastrectomy; LRYGB, laparoscopic Roux-en-Y gastric bypass; BMI, body mass index; HOMA-IR, homoeostasis model assessment insulin resistance; stim., stimulation.

p values derived by general linear model analysis.

For each OP type, pre/post comparison was done by repeated measures analysis of variance (after surgery vs. before surgery).

C-peptide values are available in 7 subjects per group.