Table 2.

Randomized Controlled Trials of DBS for Obsessive Compulsive Disorder

Study	N	Target	Stimulation Settings	Responder Criteria	Remission Criteria	At End of Trial Responders | Remitters	Primary Study Endpoint Met?
Internal Capsule (VC/VS)
(Abelson et al., 2005)	4	Internal Capsule	130 Hz–150 Hz	≥ 35% decrease in Y-BOCS	Not assessed	25% (1)	N/A	No
(Goodman et al., 2010)	6	VC/VS	130 Hz–135 Hz	≥ 35% decrease in Y-BOCS AND final Y-BOCS score ≤ 16	Not assessed	67% (4)	N/A	Yes
(Luyten, Hendrickx, Raymaekers, Gabriels, & Nuttin, 2016)	24	Internal Capsule	85 Hz–130 Hz	≥ 35% decrease in Y-BOCS	Not assessed	67% (16)	N/A	Yes
(Barcia et al., 2019)	7	Internal Capsule	130 Hz	≥ 35% decrease in Y-BOCS	Not assessed	85% (6)	N/A	No
Subthalamic Nucleus (STN)
(Mallet et al., 2008)	8	Subthalamic Nucleus	130 Hz	≥ 25% decrease in Y-BOCS	Not assessed	75% (6)	N/A	Yes
Combined VC/VS and STN
(Tyagi et al., 2019)	6	VC/VS (Internal Capsule) and STN	130 Hz	≥ 35% decrease in Y-BOCS	Not assessed	100% (6)	N/A	Yes